Our group is interested in molecular basics of energy transduction. We concentrate on mitochondrial energy dissipating systems (uncoupling proteins – UCPs, alternative oxidases – AOXs, mitochondrial potassium channels) and their role in mitochondria under physiological and pathological conditions. We study the activity of UCPs and AOXs in different eukaryotic organisms (from unicellular microorganisms to plants and mammals), the role of UCPs in inflammation and  circulatory diseases, mitochondrial potassium channels in cytoprotection, and changes in mitochondrial function due to endurance training. On the other hand, we focus on anhydrobiosis as a cytoprotective and anti-aging strategy. In particular, we are interested in the role of mitochondria in tardigrade anhydrobiosis. We are also interested in the role of VDAC channel in adaptation to environment. Moreover, we perform research on mitochondrial markers in progression of neurodegenerative diseases as well as mitochondrial causes of infertility in men.

Publication in PubMed
4
Professors
3
Assistant Professors
8
PhD Students
122
Articles (since 2010)

Our Team

  • Hanna Kmita

    Hanna Kmita

    prof. dr hab.

    head of Department
    mitochondria-mediated cytoprotection and cytotoxicity; anhydrobiosis as anti-aging strategy; the role of VDAC in adaptation to habitat conditions

    kmita@amu.edu.pl
    61 829 59 02

  • Wiesława Jarmuszkiewicz

    Wiesława Jarmuszkiewicz

    prof. dr hab.

    Cellular oxidative metabolism; regulation of activity and physiological role of mitochondrial energy-dissipating pathways, i.e., uncoupling proteins, alternative oxidases and potassium channels in various groups of eukaryotes; mitochondria and endurance training; mitochondria and endothelial cell dysfunction; coenzyme Q and oxidative stress

    wiesiaj@amu.edu.pl
    61 829 58 81

  • Nina Antos-Krzemińska

    Nina Antos-Krzemińska

    dr hab., prof UAM

    Energy dissipating systems in mitochondria – alternative dehydrogenases NAD(P)H, uncoupling proteins, alternative oxidase

    ninax@amu.edu.pl
    61 829 59 01

  • Andrzej Woyda-Płoszczyca

    Andrzej Woyda-Płoszczyca

    dr hab.

    the role of mitochondrial nucleoside-diphosphate kinase (mNDPK) in regulation of proton leak mediated by uncoupling protein (UCP) and ADP/ATP carrier (AAC)

    awoy@amu.edu.pl
    61 829 59 01

  • Andonis Karachitos

    Andonis Karachitos

    dr

    the role of VDAC3 in male infertility, impact of human VDAC isoforms on mitochondria functioning, VDAC interaction with cytoprotective and cytotoxic factors, heterologous expression of the mitochondrial outer membrane channels, fluorescence-based imaging of mitochondrial functional state in active and anhydrobiotic tardigrades

    andonis@amu.edu.pl
    61 829 59 01

  • Małgorzata Wojtkowska

    Małgorzata Wojtkowska

    dr hab.

    evolutionary and functional aspects of the mitochondrial protein import machinery, the role of mitochondria in Parkinson disease

    woytek@amu.edu.pl
    61 829 59 02

  • Anna Kicińska

    Anna Kicińska

    dr

    mitochondrial potassium channels

    anias@amu.edu.pl
    61 829 5901

  • Milena Roszkowska

    Milena Roszkowska

    PhD Student

    mitochondrial markers of successful tardigrade anhydrobiosis: metabolomic approach

    mr17357@amu.edu.pl
    61 829 58 82

  • Karolina Dominiak

    Karolina Dominiak

    PhD Student

    The interplay between mitochondrial reactive oxygen species formation and coenzyme Q reduction level

    karogr@amu.edu.pl
    829 58 76

  • Martyna Baranek

    Martyna Baranek

    PhD Student

    Functional analysis of human VDAC paralogues

    martyna.baranek@amu.edu.pl
    61 829 58 82

  • Amit Kumar Nagwani

    Amit Kumar Nagwani

    PhD Student

    anhydrobiosis as an anti-aging strategy: testing of the „Sleeping Beauty” and “Picture of Dorian Gray” models with tardigrades

    aminag@amu.edu.pl
    61 829 58 82

  • Wojciech Grabiński

    Wojciech Grabiński

    PhD Student

    Functional analysis of yeast VDAC paralogues

    wojciech.grabinskie@amu.edu.pl
    61 829 58 82

  • Tomasz Bartylak

    Tomasz Bartylak

    PhD Student

    Metabolic basis of tardigrades resistance to potassium cyanide

    tomasz.bartylak@amu.edu.pl
    61 829 58 82

  • Adrianna Budzińska

    Adrianna Budzińska

    PhD Student

  • Krzysztof Wójcicki

    Krzysztof Wójcicki

    PhD Student

  • Danuta Drachal-Chrul

    Danuta Drachal-Chrul

    technician

    technician

    dandra@amu.edu.pl
    61 829 58 75

  • Wioletta Nobik

    Wioletta Nobik

    technician

    technician

    wiolan@amu.edu.pl
    61 829 58 76

  • Ewa Kosicka

    Ewa Kosicka

    dr

    The yeast system in studies of channel proteins

    ewatom@amu.edu.pl
    tel. 61 829 5876